Chelsea will look to rest a few of the players who struggled through two hours of football in midweek.
Defenders John Terry and David Luiz are doubts, who both looked tired and jaded near the end of the Napoli encounter, with new signing Gary Cahill ready to step in should he be needed.
Midfielder Raul Meireles is back from a suspension, and Di Matteo will no doubt have one eye on the midweek game against Manchester City, possibly resting a few big names.
Leicester have PaulKonchesky back after serving a three-match man, whilst Danny Drinkwater is cup-tied for the Midlands side.
The hosts have won this competition is 3 out of the last 6 seasons, while this is a rare stage for the visitors, not reaching the quarter-finals in any of the last 7 seasons, and you have to go back 30 years since they progressed to the final four.
Despite being the only Championship side left, they knocked out Premier League opposition in the last round, beating Norwich 2-1 at Carrow Road. They also have a joint top scorer in the FA Cup this season, Jermaine Beckford has got five this season, as well as 14 in his last 15 games in all competitions.
By Brad Smith